SYRE: Spyre Therapeutics, Inc. Stock

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SIC 2834 – Pharmaceutical Preparations

Valuation
Market Cap ($M) 933.38
Enterprise Value ($M) 999.78
Book Value ($M) 517.80
Book Value / Share 8.59
Price / Book 1.80
NCAV ($M) 517.79
NCAV / Share 8.59
Price / NCAV 1.80

Profitability (mra)
Return on Invested Capital (ROIC) -0.40
Return on Assets (ROA) -0.43
Return on Equity (ROE) -1.37

Liquidity (mrq)
Quick Ratio 11.26
Current Ratio 11.26

Balance Sheet (mrq) ($M)
Current Assets 608.47
Assets 608.48
Liabilities 90.68
Debt n/a
Equity n/a

Income Statement (mra) ($M)
Revenue 0.00
Operating Income -208.57
Net Income -208.02
Earnings Per Share Basic And Diluted n/a

Cash Flow Statement (mra) ($M)
Cash From Operations -157.41
Cash from Investing -353.29
Cash from Financing 410.91

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File Date Form Activist 13D/G Investors Ownership
(%)		 Change
(%)
02-14 13G/A Rtw Investments, Lp 6.20 62.22
02-14 13G/A Venrock Healthcare Capital Partners III, L.P. 4.60 0.00
02-14 13G/A Perceptive Advisors Llc 4.40 -10.37
11-14 13G/A Avoro Capital Advisors LLC 1.70 -51.88
11-14 13G/A Commodore Capital Lp 3.90 2.79
11-12 13G/A Fmr Llc 15.00 15.81
11-08 13G BlackRock, Inc. 5.20 0.00
10-23 13G Deutsch Peter E. 6.99
04-25 13D/A Fairmount Funds Management LLC 11.17 439.01

Top 13F Investors Shares
(1000)		 Change
(%)		 Value
($1000)		 Change
(%)

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Date Insider Trades Code Shares Value

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File Date Form SEC Filings
2025-02-27 10-K re UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K
2024-11-18 10-Q/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q/A (Amendment No. 1)
2024-11-18 10-Q/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q/A (Amendment No. 1)
2024-11-18 10-Q/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q/A (Amendment No. 1)
2024-11-18 10-K/A re UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K/A (Amendment No. 2)
2024-11-07 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q
2024-08-07 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q
2024-05-09 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

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Short Volume
Market Date Short Volume Total Volume Short Volume Ratio
2025-04-03 253,272 865,516 29.26
2025-04-02 156,548 472,601 33.12
2025-04-01 234,267 1,130,386 20.72
2025-03-31 203,279 585,824 34.70

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Similar Companies
STTK – Shattuck Labs, Inc. SVRA – Savara Inc.
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TECH – Bio-Techne Corporation


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